Abstract
Azide and phosphoramidite functions were found to be compatible within one molecule and stable for months in solution kept frozen at -20 °C. An azide-carrying phosphoramidite was used for direct introduction of multiple azide modifications into synthetic oligonucleotides. A series of azide-containing oligonucleotides were modified further using click reactions with alkynes.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkynes / chemistry
-
Azides / chemical synthesis*
-
Azides / chemistry
-
Click Chemistry
-
Molecular Structure
-
Oligonucleotides / chemical synthesis*
-
Oligonucleotides / chemistry
-
Organophosphorus Compounds / chemical synthesis*
-
Organophosphorus Compounds / chemistry
Substances
-
Alkynes
-
Azides
-
Oligonucleotides
-
Organophosphorus Compounds
-
phosphoramidite