Abstract
ABO sensitization is a barrier to ABO-incompatible heart transplantation in infants. We investigate the development of ABO antibodies in infants with and without mechanical circulatory support (MCS) during their waiting period. Although the proportion of patients with antibodies was similar between the groups, the median age at antibody detection was only 9 days (6-198) for MCS vs. 223 days (28-367) for non-MCS patients (P = 0.028), suggesting MCS is associated with earlier ABO antibody detection.
MeSH terms
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ABO Blood-Group System*
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Blood Group Incompatibility / complications
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Blood Group Incompatibility / immunology*
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Child, Preschool
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Cohort Studies
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Extracorporeal Membrane Oxygenation / adverse effects*
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Female
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Graft Rejection / etiology
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Graft Rejection / immunology
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Heart Transplantation* / adverse effects
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Heart-Assist Devices / adverse effects*
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Humans
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Infant
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Infant, Newborn
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Isoantibodies / blood*
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Male
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Retrospective Studies
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Risk Factors
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Time Factors
Substances
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ABO Blood-Group System
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Isoantibodies