Abstract
Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / metabolism*
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DNA Helicases / genetics
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DNA Helicases / metabolism*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Dosage Compensation, Genetic*
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Drosophila Proteins / genetics*
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Drosophila Proteins / metabolism*
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Drosophila melanogaster / genetics*
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Drosophila melanogaster / metabolism
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Female
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Male
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Molecular Sequence Data
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RNA, Long Noncoding / metabolism*
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RNA-Binding Proteins / genetics*
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RNA-Binding Proteins / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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X Chromosome
Substances
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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Drosophila Proteins
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Pabp2 protein, Drosophila
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RNA, Long Noncoding
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RNA-Binding Proteins
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Transcription Factors
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UNR protein, Drosophila
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mle protein, Drosophila
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DNA Helicases