RNA switch at enhancers

Nat Genet. 2014 Sep;46(9):929-31. doi: 10.1038/ng.3074.

Abstract

Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.

Publication types

  • Comment

MeSH terms

  • Animals
  • Chromosomal Proteins, Non-Histone / genetics*
  • Drosophila Proteins / genetics*
  • Genes, Switch*
  • Polycomb-Group Proteins / genetics*
  • RNA, Untranslated*
  • Response Elements*
  • Transcription, Genetic*

Substances

  • Chromosomal Proteins, Non-Histone
  • Drosophila Proteins
  • Polycomb-Group Proteins
  • RNA, Untranslated
  • trx protein, Drosophila