Sudden death due to subarachnoid haemorrhage in an infant with autosomal dominant polycystic kidney disease

Kah Mean Thong; Albert C M Ong

doi:10.1093/ndt/gfu014

Sudden death due to subarachnoid haemorrhage in an infant with autosomal dominant polycystic kidney disease

Nephrol Dial Transplant. 2014 Sep:29 Suppl 4:iv121-3. doi: 10.1093/ndt/gfu014.

Authors

Kah Mean Thong¹, Albert C M Ong¹

Affiliation

¹ Kidney Genetics Group, Academic Nephrology Unit, University of Sheffield Medical School, Sheffield, UK Sheffield Kidney Institute, Sheffield Teaching Hospitals Foundation Trust, Sheffield, UK.

PMID: 25165178
DOI: 10.1093/ndt/gfu014

Abstract

Intracranial aneurysm rupture is the most serious and potentially lethal extra-renal manifestation of autosomal dominant polycystic kidney disease (ADPKD). Almost all cases of ruptured intracranial aneurysm occur in adult patients with a median age of rupture of 40 years. We report the occurrence of sudden death in a newborn infant born to a mother with typical ADPKD in the first week of life. Post-mortem examination revealed the cause of death to be subarachnoid haemorrhage with focal glomerular and tubular cysts detected in the kidney. This is the earliest reported case of intracranial aneurysm rupture in ADPKD and should raise awareness of this rare but lethal complication in younger patients.

Keywords: autosomal dominant polycystic kidney disease; intracranial aneurysm rupture; subarachnoid haemorrhage.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aneurysm, Ruptured / complications
Humans
Infant, Newborn
Intracranial Aneurysm / complications
Male
Middle Aged
Polycystic Kidney, Autosomal Dominant / complications*
Subarachnoid Hemorrhage / complications*
Sudden Infant Death / etiology*