Integrated CT-perfusion shows no meaningful correlation with PSA and presurgical Gleason score in patients with early prostate cancer

Clin Imaging. 2014 Nov-Dec;38(6):850-7. doi: 10.1016/j.clinimag.2014.07.011. Epub 2014 Aug 2.

Abstract

Objectives: To analyze the correlation of computed tomography (CT) perfusion parameters blood flow (BF), blood volume (BV), and mean transit time (MTT) with presurgical prostate cancer data.

Methods: Ninety-eight patients with biopsy-proven prostate cancer underwent a CT-perfusion scan of the prostate. MTT, BF, and BV were determined and correlated with prostate-specific antigen (PSA) level, tumor load and Gleason score of transrectal ultrasonography-guided biopsy specimens.

Results: Mean BF was 41.3 ml/100 ml*min(-1), BV 5.2 ml/100 ml, MTT 8.7 s. Moderate correlations were observed between Gleason score and BF (0.35) and between PSA and BF (0.33) and BV (0.30).

Conclusions: CT-perfusion shows no valuable correlation with presurgical prostate cancer data.

Keywords: Biopsy; CT-perfusion; Computed tomography; Gleason score; Prostate cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biopsy
  • Blood Volume
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Preoperative Care / methods*
  • Prospective Studies
  • Prostate / blood supply
  • Prostate / diagnostic imaging
  • Prostate / pathology
  • Prostate-Specific Antigen / blood*
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / pathology*
  • Tomography, X-Ray Computed / methods*

Substances

  • Prostate-Specific Antigen