Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?

Tongzhi Wu; Sony S Thazhath; Michelle J Bound; Karen L Jones; Michael Horowitz; Christopher K Rayner

doi:10.1016/j.diabres.2014.08.004

Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?

Diabetes Res Clin Pract. 2014 Oct;106(1):e3-6. doi: 10.1016/j.diabres.2014.08.004. Epub 2014 Aug 12.

Authors

Tongzhi Wu¹, Sony S Thazhath¹, Michelle J Bound¹, Karen L Jones¹, Michael Horowitz¹, Christopher K Rayner²

Affiliations

¹ Discipline of Medicine, The University of Adelaide, Adelaide, South Australia 5000, Australia; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia 5000, Australia.
² Discipline of Medicine, The University of Adelaide, Adelaide, South Australia 5000, Australia; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia 5000, Australia. Electronic address: [email protected].

PMID: 25172519
DOI: 10.1016/j.diabres.2014.08.004

Abstract

Metformin was reported to increase plasma intact glucagon-like peptide-1 (GLP-1) concentrations in type 2 diabetes. This is, at least partly, attributable to stimulation of GLP-1 secretion. A reduction in soluble dipeptidyl peptidase-4 activity may also make a modest contribution.

Keywords: Dipeptidyl peptidase-4; Enteral nutrition; Glucagon-like peptide-1; Metformin.

Publication types

Comparative Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Blood Glucose / analysis
Cross-Over Studies
Diabetes Mellitus, Type 2 / blood*
Diabetes Mellitus, Type 2 / drug therapy
Dipeptidyl Peptidase 4 / metabolism*
Glucagon-Like Peptide 1 / blood*
Glucagon-Like Peptide 1 / metabolism
Humans
Hypoglycemic Agents / therapeutic use*
Male
Metformin / therapeutic use*
Middle Aged
Retrospective Studies

Substances

Blood Glucose
Hypoglycemic Agents
Glucagon-Like Peptide 1
Metformin
DPP4 protein, human
Dipeptidyl Peptidase 4