Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes

Chem Commun (Camb). 2014 Oct 18;50(81):12173-6. doi: 10.1039/c4cc05394j.

Abstract

A novel 2,4,5-triaryl-substituted imidazole (IZCM-1) has been found to display distinct and specific fluorescence enhancement upon binding to parallel G-quadruplexes. Such a sensitive and topology-specific probe is able to light up without affecting the topology or thermal stability of the G-quadruplex sample. Thus, these advantages distinguish IZCM-1 from other G-quadruplex probes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coumarins / chemical synthesis
  • Coumarins / chemistry*
  • Fluorescent Dyes / chemistry*
  • G-Quadruplexes*
  • Imidazoles / chemical synthesis
  • Imidazoles / chemistry*
  • Molecular Dynamics Simulation
  • Spectrometry, Fluorescence
  • Thermodynamics

Substances

  • Coumarins
  • Fluorescent Dyes
  • IZCM-1 compound
  • Imidazoles
  • imidazole