The prevalence of dental caries in the school children population in Rieti is very high, according to low levels of fluoride content in drinkable water, similar to those detected in other areas of Italy and Europe. The aim of our research is to propose a combined prevention protocol, utilizing fluoride tablets and dental therapy through structures already existing in the public health national organization. The application of this combined (profilaxis-therapy) protocol is expected to decrease the prevalence of dental caries to 50% in a five years period, at a very accettable cost. This protocol should find early application, possibly starting from maternal schools.