Abstract
The first enantioselective aza-Morita–Baylis–Hillman reaction of acrylates with ketimines derived from isatins has been developed. With 2 mol% of chiral bifunctional phosphine-squaramide 4e, optically active 3-substituted-3-amino-2-oxindoles were obtained in excellent yields with up to 91% ee.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylates / chemistry*
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Crystallography, X-Ray
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Imines / chemistry*
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Indoles / chemical synthesis*
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Indoles / chemistry
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Models, Molecular
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Molecular Structure
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Nitriles / chemistry*
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Oxindoles
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Stereoisomerism
Substances
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3-amino-2-oxindole
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Acrylates
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Imines
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Indoles
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Nitriles
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Oxindoles
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ketimine