Capturing glimpses of an elusive HIV gp41 prehairpin fusion intermediate

Lukas K Tamm; Jinwoo Lee; Binyong Liang

doi:10.1016/j.str.2014.08.010

Capturing glimpses of an elusive HIV gp41 prehairpin fusion intermediate

Structure. 2014 Sep 2;22(9):1225-1226. doi: 10.1016/j.str.2014.08.010.

Authors

Lukas K Tamm¹, Jinwoo Lee², Binyong Liang²

Affiliations

¹ Center for Membrane Biology and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address: [email protected].
² Center for Membrane Biology and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Abstract

Nuclear magnetic resonance (NMR) studies on an HIV gp41 construct reported by Lakomek and colleagues in this issue of Structure have revealed the conformational dynamics of a possible trimeric prehairpin fusion intermediate and its interactions with lipids. Two alternative fusion pathways are compared based on this work and a previous NMR structure of a monomeric lipid-bound gp41 ectodomain construct.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

HIV Envelope Protein gp41 / chemistry*
Phosphorylcholine / analogs & derivatives*
Phosphorylcholine / chemistry

Substances

HIV Envelope Protein gp41
gp41 protein, Human immunodeficiency virus 1
Phosphorylcholine
dodecylphosphocholine

Abstract

Publication types

MeSH terms

Substances

Grants and funding