Stem cell lineage specification: you become what you eat

Cell Metab. 2014 Sep 2;20(3):389-91. doi: 10.1016/j.cmet.2014.08.006.

Abstract

Nutrient availability and intermediate metabolism are increasingly recognized to govern stem cell behavior. Oburoglu et al. (2014) now demonstrate that glutamine- and glucose-dependent nucleotide synthesis segregate erythroid versus myeloid differentiation during hematopoietic stem cell specification, implicating a metabolism-centric regulation of lineage choices.

Publication types

  • Comment

MeSH terms

  • Amino Acid Transport System ASC / metabolism*
  • Animals
  • Cell Lineage*
  • Gene Expression Regulation*
  • Glucose / metabolism*
  • Glutamine / metabolism*
  • Hematopoietic Stem Cells / cytology*
  • Humans
  • Minor Histocompatibility Antigens

Substances

  • Amino Acid Transport System ASC
  • Minor Histocompatibility Antigens
  • SLC1A5 protein, human
  • Glutamine
  • Glucose