The role of the duty factor in ultrasound-mediated cardiac stimulation

Olivia C Coiado; William D O'Brien Jr

doi:10.1121/1.4893332

The role of the duty factor in ultrasound-mediated cardiac stimulation

J Acoust Soc Am. 2014 Sep;136(3):EL231. doi: 10.1121/1.4893332.

Authors

Olivia C Coiado¹, William D O'Brien Jr¹

Affiliation

¹ Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 405 North Mathews, Urbana, Illinois 61801 [email protected], [email protected].

Abstract

The role of the duty factor (DF) in ultrasound-mediated cardiac stimulation is studied. Five 3-month-old female rats were exposed transthoracically to 3.5-MHz ultrasonic pulses of 2.0-MPa peak rarefactional pressure amplitude, variable DF, and variable pulse repetition frequency. A change in the heart rate was not observed following the 0.25%-DF sequence. A decrease of ∼4% in the heart rate was observed following the 0.50%-DF and 1.00%-DF sequences. Outcomes suggest a possible DF threshold for cardiac pacing.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Bradycardia / physiopathology*
Cardiac Pacing, Artificial / methods*
Female
Heart Rate*
Models, Animal
Rats, Sprague-Dawley
Time Factors
Ultrasonics / methods*

Grants and funding

R37 EB002641/EB/NIBIB NIH HHS/United States