This report concerns the observations the Authors have been carrying out for over twelve years in Sardinia; they regard the sensitization to house dust mites (Dermatophagoides pteronyssinus, Dermatophagoides farinae) and to storage mites (Acarus siro, Glycyphagus domesticus, Lepidoglyphus destructor, Tyrophagus putrescentiae) and are been obtained with: 1) skin tests with mite extracts; 2) RadioAllergoSorbentTest (RAST) for specific IgE and IgG; 3) mite exposure in homes and mite analysis; 4) hyposensitisation with personal time-lag vaccines holding one or more "storage" or "house dust" mites. They are been prepared on the ground of RAST, skin tests, clinical symptomatology and environmental exposure to mites; 5) clinical control after therapy with vaccines for a period of five till to ten years. The Authors obtained unusual results.