Abstract
The increasing incidence of multidrug-resistant tuberculosis (MDR-TB) and the emergence of extensively drug-resistant tuberculosis (XDR-TB) globally hamper the successful treatment and effective control of TB. Information on second-line drug susceptibility, which is of utmost importance for patient care, is still limited. This study demonstrates the susceptibilities of 1447 strains of MDR-TB, including 58 XDR-TB strains, isolated from Siriraj Hospital, Bangkok, Thailand, to aminoglycosides, fluoroquinolones, ethionamide (ETH), para-aminosalicylic acid (PAS) and linezolid. Results revealed that 93-94% of the MDR-TB strains were susceptible to aminoglycosides, 85-98% to fluoroquinolones, 78% to ETH, 85% to PAS and 99% to linezolid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / pharmacology
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Aminoglycosides / pharmacology
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Antitubercular Agents / pharmacology*
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Extensively Drug-Resistant Tuberculosis / drug therapy*
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Extensively Drug-Resistant Tuberculosis / epidemiology
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Extensively Drug-Resistant Tuberculosis / microbiology
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Fluoroquinolones / pharmacology
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Humans
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Linezolid
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / isolation & purification
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Oxazolidinones / pharmacology
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Thailand / epidemiology
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Tuberculosis, Multidrug-Resistant / drug therapy*
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Tuberculosis, Multidrug-Resistant / epidemiology
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Tuberculosis, Multidrug-Resistant / microbiology
Substances
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Acetamides
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Aminoglycosides
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Antitubercular Agents
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Fluoroquinolones
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Oxazolidinones
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Linezolid