Complexity of lower extremity peripheral artery disease reflects the complexity of coronary artery disease

Vascular. 2015 Aug;23(4):366-73. doi: 10.1177/1708538114550738. Epub 2014 Sep 10.

Abstract

We investigated the relationship between peripheral artery disease complexity and coronary artery disease complexity in patients with peripheral artery disease. A total of 449 patients were enrolled. SYNTAX score, a marker of coronary artery disease complexity, was assessed by dedicated computer software and complexity of peripheral artery disease was determined by Trans Atlantic Inter-Society Consensus II classification. The SYNTAX score of patients with minimal peripheral artery disease, Trans Atlantic Inter-Society Consensus A, Trans Atlantic Inter-Society Consensus B, Trans Atlantic Inter-Society Consensus C and Trans Atlantic Inter-Society Consensus D were 5 (11), 12.5 (13.25), 20 (14), 20.5 (19) and 27.5 (19), respectively (values in brackets represent the interquartile range). SYNTAX score and Trans Atlantic Inter-Society Consensus class was moderately correlated (r = 0.495, p < 0.001). In multivariate regression analysis male sex (B = 0.169, p < 0.001, CI95% = 0.270-0.735), Log10 SYNTAX score (B = 0.282, p < 0.001, CI95% = 0.431-0.782), Log10 creatinine (B = 0.081, p = 0.036, CI95% = 0.043-1.239), low-density lipoprotein (B = 0.114, p = 0.003, CI95% = 0.001-0.006) and high-density lipoprotein (B = -0.360, p < 0.001, CI95% = -0.063 to -0.041) were the independent predictors of Trans Atlantic Inter-Society Consensus II class. We have shown that patients with complex peripheral artery disease had complex coronary artery disease.

Keywords: Peripheral; SYNTAX; Trans Atlantic Inter-Society Consensus; angiography; artery; coronary.

MeSH terms

  • Aged
  • Biomarkers / blood
  • Chi-Square Distribution
  • Coronary Angiography
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / diagnosis*
  • Coronary Artery Disease / diagnostic imaging
  • Creatinine / blood
  • Cross-Sectional Studies
  • Female
  • Humans
  • Lipoproteins, HDL / blood
  • Lipoproteins, LDL / blood
  • Lower Extremity / blood supply*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Peripheral Arterial Disease / blood
  • Peripheral Arterial Disease / classification
  • Peripheral Arterial Disease / diagnosis*
  • Peripheral Arterial Disease / diagnostic imaging
  • Predictive Value of Tests
  • Retrospective Studies
  • Risk Factors
  • Severity of Illness Index
  • Sex Factors

Substances

  • Biomarkers
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Creatinine