Alkaline earth catalysis for the 100% atom-efficient three component assembly of imidazolidin-2-ones

Merle Arrowsmith; William M S Shepherd; Michael S Hill; Gabriele Kociok-Köhn

doi:10.1039/c4cc05223d

Alkaline earth catalysis for the 100% atom-efficient three component assembly of imidazolidin-2-ones

Chem Commun (Camb). 2014 Oct 28;50(84):12676-9. doi: 10.1039/c4cc05223d.

Authors

Merle Arrowsmith¹, William M S Shepherd, Michael S Hill, Gabriele Kociok-Köhn

Affiliation

¹ Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK. [email protected].

PMID: 25209547
DOI: 10.1039/c4cc05223d

Abstract

A variety of functionalised imidazolidin-2-ones may be synthesised under very mild reaction conditions using non-toxic and cost-effective alkaline earth bis(amide) pre-catalysts in a 100% atom-efficient, intermolecular one-pot assembly from inexpensive alkyne and cumulene reagents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Crystallography, X-Ray
Cyclization
Imidazolidines / chemical synthesis
Imidazolidines / chemistry*
Isocyanates / chemistry
Metals, Alkaline Earth / chemistry*
Molecular Conformation
Stereoisomerism

Substances

Imidazolidines
Isocyanates
Metals, Alkaline Earth
ethylene urea