Between-muscle differences in the adaptation to experimental pain

J Appl Physiol (1985). 2014 Nov 15;117(10):1132-40. doi: 10.1152/japplphysiol.00561.2014. Epub 2014 Sep 11.

Abstract

This study aimed to determine whether muscle stress (force per unit area) can be redistributed between individual heads of the quadriceps muscle when pain is induced into one of these heads. Elastography was used to measure muscle shear elastic modulus (an index of muscle stress). Electromyography (EMG) was recorded from vastus lateralis (VL), vastus medialis (VM), and rectus femoris (RF). In experiment I (n = 20), participants matched a knee extension force, and thus any reduction of stress within the painful muscle would require compensation by other muscles. In experiment II (n = 13), participants matched VL EMG amplitude and were free to vary external force such that intermuscle compensation would be unnecessary to maintain the experimental task. In experiments I and II, pain was induced by injection of hypertonic saline into VM or RF. Experiment III aimed to establish whether voluntary drive to the individual muscles could be controlled independently. Participants (n = 13) were asked to voluntarily reduce activation of VM or RF while maintaining knee extension force. During VM pain, there was no change in shear elastic modulus (experiments I and II) or EMG amplitude of VM (experiment II). In contrast, RF pain was associated with a reduction in RF elastic modulus (experiments I and II: -8 to -17%) and EMG amplitude (experiment II). Participants could voluntarily reduce EMG amplitude of RF (-26%; P = 0.003) but not VM (experiment III). These results highlight between-muscle differences in adaptation to pain that might be explained by their function (monoarticular vs. biarticular) and/or the neurophysiological constraints associated to their activation.

Keywords: elastography; electromyography; noxious stimulation; quadriceps; supersonic shear imaging.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological
  • Adaptation, Psychological
  • Adult
  • Biomechanical Phenomena
  • Elastic Modulus
  • Elasticity Imaging Techniques
  • Electromyography
  • Female
  • Humans
  • Isometric Contraction*
  • Male
  • Muscle Strength*
  • Myalgia / diagnosis
  • Myalgia / physiopathology*
  • Myalgia / psychology
  • Neurofeedback
  • Pain Measurement
  • Pain Perception
  • Pain Threshold*
  • Quadriceps Muscle / diagnostic imaging
  • Quadriceps Muscle / physiopathology*
  • Volition
  • Young Adult