Distinctive tRNA repertoires in proliferating versus differentiating cells

Ivan Topisirovic; Nahum Sonenberg

doi:10.1016/j.cell.2014.08.031

Distinctive tRNA repertoires in proliferating versus differentiating cells

Cell. 2014 Sep 11;158(6):1238-1239. doi: 10.1016/j.cell.2014.08.031.

Authors

Ivan Topisirovic¹, Nahum Sonenberg²

Affiliations

¹ Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada; Department of Oncology, McGill University, Montreal, Quebec H3T 1E2, Canada. Electronic address: [email protected].
² Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, Canada; Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada. Electronic address: [email protected].

PMID: 25215483
DOI: 10.1016/j.cell.2014.08.031

Abstract

Transfer RNAs (tRNAs) deliver amino acids to the ribosome during mRNA translation. Gingold et al. now provide evidence that alterations in the cellular tRNA repertoire are tightly coordinated with changes in mRNA expression. These changes in the tRNA repertoire dictate translational programs that distinguish differentiating from proliferating cells.

Publication types

Comment

MeSH terms

Cell Differentiation*
Cell Proliferation*
Humans
Protein Biosynthesis*
RNA, Transfer / genetics*

Substances

RNA, Transfer