Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain

Cell Rep. 2014 Sep 25;8(6):1697-1703. doi: 10.1016/j.celrep.2014.08.014. Epub 2014 Sep 15.

Abstract

The differentiation capability of induced pluripotent stem cells (iPSCs) toward certain cell types for disease modeling and drug screening assays might be influenced by their somatic cell of origin. Here, we have compared the neural induction of human iPSCs generated from fetal neural stem cells (fNSCs), dermal fibroblasts, or cord blood CD34(+) hematopoietic progenitor cells. Neural progenitor cells (NPCs) and neurons could be generated at similar efficiencies from all iPSCs. Transcriptomics analysis of the whole genome and of neural genes revealed a separation of neuroectoderm-derived iPSC-NPCs from mesoderm-derived iPSC-NPCs. Furthermore, we found genes that were similarly expressed in fNSCs and neuroectoderm, but not in mesoderm-derived iPSC-NPCs. Notably, these neural signatures were retained after transplantation into the cortex of mice and paralleled with increased survival of neuroectoderm-derived cells in vivo. These results indicate distinct origin-dependent neural cell identities in differentiated human iPSCs both in vitro and in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD34 / metabolism
  • Brain / metabolism*
  • Cell Differentiation
  • Cells, Cultured
  • Fetal Blood / cytology
  • Fetal Blood / metabolism
  • Fetus / cytology
  • Fibroblasts / cytology
  • Gene Expression Profiling
  • Green Fluorescent Proteins / genetics
  • Green Fluorescent Proteins / metabolism
  • Hematopoietic Stem Cells / cytology
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / metabolism
  • Induced Pluripotent Stem Cells / transplantation
  • Mesoderm / cytology
  • Mice
  • Mice, Inbred NOD
  • Microscopy, Confocal
  • Neural Plate / cytology
  • Neural Stem Cells / cytology*

Substances

  • Antigens, CD34
  • Green Fluorescent Proteins

Associated data

  • GEO/GSE55107