Synthesis of phenanthridine derivatives via cascade annulation of diaryliodonium salts and nitriles

Org Biomol Chem. 2014 Oct 28;12(40):7904-8. doi: 10.1039/c4ob01504e.

Abstract

A cascade coupling reaction toward a variety of phenanthridine derivatives has been developed. This cascade transformation proceeds via the copper-catalyzed coupling reaction of diaryliodonium salts and nitriles, and undergoes cyclization into the phenanthridine core.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Copper / chemistry
  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Structure
  • Nitriles / chemistry*
  • Onium Compounds / chemistry*
  • Organometallic Compounds / chemistry
  • Phenanthridines / chemical synthesis*
  • Phenanthridines / chemistry

Substances

  • Nitriles
  • Onium Compounds
  • Organometallic Compounds
  • Phenanthridines
  • Copper