Brain abscesses in children: results of 24 children from a reference center in Central Anatolia, Turkey

J Child Neurol. 2015 Mar;30(4):458-67. doi: 10.1177/0883073814549247. Epub 2014 Sep 15.

Abstract

Childhood brain abscesses are a rare and potentially life-threatening condition requiring urgent diagnosis and treatment. This retrospective study analyzed the clinical and radiologic findings of 24 (7 girl, 17 boys) cases with brain abscess. Mean age was 92.98 ± 68.04 months. The most common presenting symptoms were nausea-vomiting (45.8%) and headache (41.7%). Brain abscess was most commonly located in the frontal region. Diffusion restriction was determined in 78.4% of lesions. The mean apparent diffusion coefficient value in these lesions was 0.511 ± 0.23 × 10(-3) mm(2)/s. Cultures were sterile in 40% of cases. Antimicrobial therapy was given to only 16.7% of cases. Predisposing factors were identified in 91.6% of cases (congenital heart disease in 20.8% and immunosuppression in 20.8%). Mortality level was 12.5%. In conclusion, immunocompromised states, and congenital heart disease have become an important predisposing factor for brain abscesses. Effective and prompt management should ensure better outcome in childhood.

Keywords: brain abscess; child; clinical and radiologic features.

MeSH terms

  • Brain / pathology
  • Brain Abscess / mortality
  • Brain Abscess / pathology*
  • Brain Abscess / physiopathology*
  • Brain Abscess / therapy
  • Child
  • Female
  • Heart Defects, Congenital / complications
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Retrospective Studies
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Turkey / epidemiology