Chronic hepatitis B virus coinfection is associated with renal impairment among Zambian HIV-infected adults

Clin Infect Dis. 2014 Dec 15;59(12):1757-60. doi: 10.1093/cid/ciu734. Epub 2014 Sep 16.

Abstract

Among 6789 HIV-infected Zambian adults screened for hepatitis B virus (HBV) coinfection, estimated glomerular filtration rate (eGFR) was 50-90 mL/minute/1.73 m(2) in 17.6% and <50 mL/minute/1.73 m(2) in 2.5%. Human immunodeficiency virus/HBV coinfection was associated with eGFR <50 mL/minute/1.73 m(2) (adjusted odds ratio, 1.96 [95% confidence interval, 1.34-2.86]), adjusted for age, sex, CD4(+) count, and World Health Organization disease stage.

Keywords: Africa; HIV/AIDS; hepatitis B virus; renal dysfunction; tenofovir.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives
  • Adenine / therapeutic use
  • Adolescent
  • Adult
  • Africa
  • Anti-HIV Agents / therapeutic use
  • Coinfection
  • Female
  • Glomerular Filtration Rate / physiology
  • HIV / pathogenicity*
  • Hepatitis B, Chronic / complications*
  • Hepatitis B, Chronic / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Organophosphonates / therapeutic use
  • Renal Insufficiency / etiology*
  • Renal Insufficiency / physiopathology
  • Tenofovir
  • Young Adult

Substances

  • Anti-HIV Agents
  • Organophosphonates
  • Tenofovir
  • Adenine