Very early ART resulting in the absence of HIV-1 antibodies and in a sustained undetectable plasma HIV-1-RNA and proviral-DNA in an HLA-B*5701 and Δ32 heterozygote HIV-1-infected patient was not associated with functional cure

J Antimicrob Chemother. 2015 Jan;70(1):317-9. doi: 10.1093/jac/dku370. Epub 2014 Sep 19.
No abstract available

Keywords: HIV primo-infection; early treatment; functional cure; reservoir.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antiretroviral Therapy, Highly Active / methods*
  • Blotting, Western
  • CD4 Lymphocyte Count
  • DNA, Viral / blood
  • Enzyme-Linked Immunosorbent Assay
  • HIV Antibodies / blood*
  • HIV Infections / drug therapy*
  • HIV-1 / immunology*
  • HIV-1 / isolation & purification
  • HLA-B Antigens / genetics*
  • Heterozygote
  • Humans
  • Male
  • Middle Aged
  • Plasma / virology
  • RNA, Viral / blood
  • Receptors, CCR5 / genetics*
  • Sequence Deletion
  • Time Factors
  • Treatment Outcome
  • Viral Load*

Substances

  • CCR5 protein, human
  • DNA, Viral
  • HIV Antibodies
  • HLA-B Antigens
  • HLA-B*57:01 antigen
  • RNA, Viral
  • Receptors, CCR5