Abstract
Tonic neurochemical dopamine activity underlies many brain functions; however a consensus on this important concentration has not yet been reached. In this work, we introduce in vivo fast-scan controlled-adsorption voltammetry to report tonic dopamine concentrations (90 ± 9 nM) and the dopamine diffusion coefficient (1.05 ± 0.09 × 10(-6) cm(2) s(-1)) in the mouse brain.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3,4-Dihydroxyphenylacetic Acid / chemistry
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3,4-Dihydroxyphenylacetic Acid / metabolism
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Adsorption
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Animals
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Ascorbic Acid / chemistry
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Ascorbic Acid / metabolism
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Brain / metabolism
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Dopamine / chemistry
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Dopamine / metabolism*
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Electrochemical Techniques
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Mice
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Monoamine Oxidase / metabolism
Substances
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3,4-Dihydroxyphenylacetic Acid
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Monoamine Oxidase
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Ascorbic Acid
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Dopamine