Tenosynovitis caused by a novel nontuberculous Mycobacterium species initially misidentified as a member of the Mycobacterium tuberculosis complex

Patricia J Simner; Emily P Hyle; Seanne P Buckwalter; John A Branda; Barbara A Brown-Elliott; Jameelah Franklin; Nadege C Toney; Tom J B de Man; Richard J Wallace Jr; Ravikiran Vasireddy; Rajesh T Gandhi; Nancy L Wengenack

doi:10.1128/JCM.00967-14

Tenosynovitis caused by a novel nontuberculous Mycobacterium species initially misidentified as a member of the Mycobacterium tuberculosis complex

J Clin Microbiol. 2014 Dec;52(12):4414-8. doi: 10.1128/JCM.00967-14. Epub 2014 Sep 24.

Affiliations

¹ Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
² Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
³ Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁴ Mycobacteria/Nocardia Laboratory, Department of Microbiology, University of Texas Health Science Center, Tyler, Texas, USA.
⁵ Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
⁶ Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
⁷ Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
⁸ Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA [email protected].

Abstract

We present a case of tenosynovitis caused by a novel, slowly growing, nonchromogenic, nontuberculous mycobacterium (NTM). Originally misidentified as Mycobacterium tuberculosis complex, the NTM cross-reacts with the M. tuberculosis complex nucleic acid hybridization probe, a M. tuberculosis gamma interferon release assay, and is closely related to M. tuberculosis by 16S rRNA gene sequencing.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Cluster Analysis
DNA, Bacterial / chemistry
DNA, Bacterial / genetics
DNA, Ribosomal / chemistry
DNA, Ribosomal / genetics
Diagnostic Errors
Diagnostic Tests, Routine
Female
Humans
Interferon-gamma Release Tests
Middle Aged
Molecular Sequence Data
Mycobacterium Infections, Nontuberculous / diagnosis*
Mycobacterium Infections, Nontuberculous / microbiology*
Mycobacterium Infections, Nontuberculous / pathology
Nontuberculous Mycobacteria / classification
Nontuberculous Mycobacteria / genetics
Nontuberculous Mycobacteria / isolation & purification*
Nucleic Acid Hybridization
Phylogeny
RNA, Ribosomal, 16S / genetics
Sequence Analysis, DNA
Tenosynovitis / diagnosis*
Tenosynovitis / microbiology*
Tenosynovitis / pathology

Substances

Anti-Bacterial Agents
DNA, Bacterial
DNA, Ribosomal
RNA, Ribosomal, 16S

Associated data

GENBANK/KF683289
GENBANK/KJ371034
GENBANK/KJ371036

Grants and funding

T32 AI007433/AI/NIAID NIH HHS/United States