[Coronary microvascular dysfunction and aortic stenosis: an update]

P Meimoun; D Czitrom

doi:10.1016/j.ancard.2014.08.015

[Coronary microvascular dysfunction and aortic stenosis: an update]

Ann Cardiol Angeiol (Paris). 2014 Nov;63(5):353-61. doi: 10.1016/j.ancard.2014.08.015. Epub 2014 Sep 9.

[Article in French]

Authors

P Meimoun¹, D Czitrom²

Affiliations

¹ Service de cardiologie-USIC, centre hospitalier de Compiègne, 8, rue Henri-Adnot, 60200 Compiègne, France. Electronic address: [email protected].
² Service de cardiologie, institut mutualiste Montsouris, 75014 Paris, France.

PMID: 25261167
DOI: 10.1016/j.ancard.2014.08.015

Abstract

The coronary microcirculatory impairment is a key feature of the pathophysiology of aortic stenosis (AS), the most operated valvular disease over the world. Several studies showed this coronary microcirculatory impairment in AS, using different tools and protocols, in various patient population of AS. This article will review the impairment of the coronary microcirculation in AS underlining its multifactorial origin, its functional part related to the hemodynamic consequences of AS, its complex relationship with left ventricular hypertrophy, and its potential diagnostic and prognostic value.

Keywords: Aortic stenosis; Coronary flow reserve; Microcirculation; Réserve coronaire; Rétrécissement aortique.

Publication types

English Abstract
Review

MeSH terms

Adult
Aged
Aortic Valve Stenosis / diagnosis*
Aortic Valve Stenosis / physiopathology*
Coronary Vessels / physiopathology*
Female
Hemodynamics / physiology
Humans
Hypertrophy, Left Ventricular / diagnosis
Hypertrophy, Left Ventricular / physiopathology
Male
Microcirculation / physiology*
Middle Aged
Prognosis