Identification of primary drug resistance to rifampin in Mycobacterium leprae strains from leprosy patients in Amazonas State, Brazil

J Clin Microbiol. 2014 Dec;52(12):4359-60. doi: 10.1128/JCM.01688-14. Epub 2014 Oct 1.

Abstract

The aim of this study was to identify polymorphisms in the folp1, gyrA, and rpoB genes in leprosy patients treated in Amazonas State, Brazil. Among 197 slit-skin smear samples from untreated or relapsed patients, we found three cases of primary resistance to rifampin and one confirmed case of multidrug resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Brazil
  • Drug Resistance, Bacterial*
  • Female
  • Humans
  • Leprosy / microbiology*
  • Male
  • Mycobacterium leprae / drug effects*
  • Mycobacterium leprae / genetics*
  • Mycobacterium leprae / isolation & purification
  • Polymorphism, Genetic
  • Rifampin / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Rifampin