Radical based strategy toward the synthesis of 2,3-dihydrofurans from aryl ketones and aromatic olefins

Org Lett. 2014 Oct 17;16(20):5446-9. doi: 10.1021/ol502688r. Epub 2014 Oct 2.

Abstract

A copper-mediated annulation of aryl ketones with a wide range of aromatic olefins has been developed. This strategy allowed convenient access to 2,3-dihydrofuran derivatives. The versatility of the protocol is shown by synthesizing α-methyl dihydrofurans, which serve as an intermediate for the synthesis of vitamin B1. In addition, the applicability of the protocol in conjugated systems is demonstrated. A radical pathway was presumed and supported for annulation of aryl ketones with olefins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis*
  • Alkenes / chemistry
  • Copper / chemistry
  • Furans / chemical synthesis*
  • Furans / chemistry
  • Ketones / chemical synthesis*
  • Ketones / chemistry
  • Molecular Structure
  • Thiamine / chemical synthesis
  • Thiamine / chemistry

Substances

  • Alkenes
  • Furans
  • Ketones
  • 2,3-dihydrofuran
  • Copper
  • Thiamine