Reinventing the neural crest: direct reprogramming makes iNCCs

Sandra Varum; Lukas Sommer

doi:10.1016/j.stem.2014.09.007

Reinventing the neural crest: direct reprogramming makes iNCCs

Cell Stem Cell. 2014 Oct 2;15(4):397-399. doi: 10.1016/j.stem.2014.09.007.

Authors

Sandra Varum¹, Lukas Sommer²

Affiliations

¹ Institute of Anatomy, University of Zurich, 8057 Zurich, Switzerland.
² Institute of Anatomy, University of Zurich, 8057 Zurich, Switzerland. Electronic address: [email protected].

PMID: 25280213
DOI: 10.1016/j.stem.2014.09.007

Abstract

Aberrant neural crest (NC) development is at the origin of many congenital diseases. Given the limitations in human NC cell isolation and expansion, the development of new strategies for NC generation is crucial. In this issue of Cell Stem Cell, Kim et al. (2014) report the direct reprogramming of postnatal fibroblasts into multipotent NC cells.

Publication types

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MeSH terms

Animals
Cellular Reprogramming*
Humans
Multipotent Stem Cells / cytology*
Neural Crest / cytology*
SOXE Transcription Factors / metabolism*

Substances

SOXE Transcription Factors