Characterization of Fe3O4/SiO2/Gd2O(CO3)2 core/shell/shell nanoparticles as T1 and T2 dual mode MRI contrast agent

Meicheng Yang; Lipeng Gao; Kai Liu; Chunhua Luo; Yiting Wang; Lei Yu; Hui Peng; Wen Zhang

doi:10.1016/j.talanta.2014.08.042

Characterization of Fe3O4/SiO2/Gd2O(CO3)2 core/shell/shell nanoparticles as T1 and T2 dual mode MRI contrast agent

Talanta. 2015 Jan:131:661-5. doi: 10.1016/j.talanta.2014.08.042. Epub 2014 Aug 26.

Authors

Meicheng Yang¹, Lipeng Gao², Kai Liu², Chunhua Luo³, Yiting Wang², Lei Yu², Hui Peng⁴, Wen Zhang⁵

Affiliations

¹ Chemistry Department, East China Normal University, Shanghai 200241, PR China; Antibiotics Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, PR China.
² Key Laboratory of Polar Materials and Devices, Ministry of Education, East China Normal University, Shanghai 200241, PR China.
³ Key Laboratory of Polar Materials and Devices, Ministry of Education, East China Normal University, Shanghai 200241, PR China. Electronic address: [email protected].
⁴ Key Laboratory of Polar Materials and Devices, Ministry of Education, East China Normal University, Shanghai 200241, PR China; Polymer Electronic Research Centre, The University of Auckland, Private Bag 92019, Auckland, New Zealand; State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, PR China. Electronic address: [email protected].
⁵ Chemistry Department, East China Normal University, Shanghai 200241, PR China.

PMID: 25281156
DOI: 10.1016/j.talanta.2014.08.042

Abstract

Core/shell/shell structured Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles were successfully synthesized. Their properties as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging were investigated. Due to the introduce of a separating SiO2 layer, the magnetic coupling between Gd2O(CO3)2 and Fe3O4 could be modulated by the thickness of SiO2 layer and produce appropriate T1 and T2 signal. Additionally, the existence of Gd(3+) enhances the transverse relaxivity of Fe3O4 possibly because of the magnetic coupling between Gd(3+) and Fe3O4. The Fe3O4/SiO2/Gd2O(CO3)2 nanoparticles exhibit good biocompatibility, showing great potential for biomedical applications.

Keywords: Contrast agents; Fe(3)O(4)/SiO(2)/Gd(2)O(CO(3))(2); Magnetic resonance imaging; Nanoparticles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Contrast Media / chemistry*
Ferric Compounds / chemistry*
Gadolinium / chemistry*
Magnetic Resonance Imaging / methods*
Magnetics
Nanoparticles / chemistry*
Silicon Dioxide / chemistry*

Substances

Contrast Media
Ferric Compounds
gadolinium oxide
Silicon Dioxide
Gadolinium