New antibacterial xanthone from the marine sponge-derived Micrococcus sp. EG45

Bioorg Med Chem Lett. 2014 Nov 1;24(21):4939-42. doi: 10.1016/j.bmcl.2014.09.040. Epub 2014 Sep 22.

Abstract

Microluside A [4 (19-para-hydroxy benzoyloxy-O-β-D-cellobiosyl), 5 (30-para-hydroxy benzoyloxy-O-β-D-glucopyranosyl) xanthone (1)] is a unique O-glycosylated disubstituted xanthone isolated from the broth culture of Micrococcus sp. EG45 cultivated from the Red Sea sponge Spheciospongia vagabunda. The structure of microluside A was determined by 1D- and 2D-NMR techniques as well as high resolution tandem mass spectrometry. The antimicrobial activity evaluation showed that 1 exhibited antibacterial potential against Enterococcus faecalis JH212 and Staphylococcus aureus NCTC 8325 with MIC values of 10 and 13 μM, respectively.

Keywords: Actinomycetes; Antimicrobial activity; Micrococcus sp.; Spheciospongia vagabunda; Xanthone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Enterococcus faecalis / drug effects*
  • Magnetic Resonance Spectroscopy
  • Micrococcus / drug effects*
  • Porifera / chemistry*
  • Staphylococcus aureus / drug effects*
  • Tandem Mass Spectrometry
  • Xanthones / chemistry
  • Xanthones / isolation & purification*

Substances

  • Anti-Bacterial Agents
  • Xanthones
  • xanthone