Synthesis of indoles using visible light: photoredox catalysis for palladium-catalyzed C-H activation

Jochen Zoller; David C Fabry; Meria A Ronge; Magnus Rueping

doi:10.1002/anie.201405478

Synthesis of indoles using visible light: photoredox catalysis for palladium-catalyzed C-H activation

Angew Chem Int Ed Engl. 2014 Nov 24;53(48):13264-8. doi: 10.1002/anie.201405478. Epub 2014 Oct 3.

Authors

Jochen Zoller¹, David C Fabry, Meria A Ronge, Magnus Rueping

Affiliation

¹ Institut of Organic Chemistry, RWTH Aachen, Landoltweg 1, 52074 Aachen (Germany).

PMID: 25284332
DOI: 10.1002/anie.201405478

Abstract

A combined palladium- and photoredox-catalyzed C-H olefination enables the synthesis of indoles. By using visible light, the direct C-H activation of aromatic enamines can be achieved and a variety of indole derivatives can be obtained in good yields under mild reaction conditions.

Keywords: CH functionalization; Heck reaction; photocatalysis; superoxide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Indoles / chemical synthesis*
Light
Molecular Structure
Palladium / chemistry*

Substances

Indoles
Palladium