Why strategies to control Leishmania spp. multiplication based on the use of proteinase inhibitors should consider multiple targets and not only a single enzyme

Carlos Roberto Alves; Bernardo Acácio Santini Pereira; Mariana Silva-Almeida; Franklin Souza da Silva

doi:10.1007/s00894-014-2465-4

Why strategies to control Leishmania spp. multiplication based on the use of proteinase inhibitors should consider multiple targets and not only a single enzyme

J Mol Model. 2014 Oct;20(10):2465. doi: 10.1007/s00894-014-2465-4. Epub 2014 Oct 9.

Authors

Carlos Roberto Alves¹, Bernardo Acácio Santini Pereira, Mariana Silva-Almeida, Franklin Souza da Silva

Affiliation

¹ Fundação Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Av. Brasil 4365, Rio de Janeiro, CEP 21040-360, Brazil, [email protected].

PMID: 25296889
DOI: 10.1007/s00894-014-2465-4

Abstract

The use of proteinases as targets to develop novel chemotherapies against Leishmania spp. infections is a very promising strategy. Based on a previous study by Goyal et al. [J Mol Model (2014) 20:2099], we discuss herein the idea that only a combined treatment with distinct proteinase inhibitors would be an effective antileishmanial therapy.

MeSH terms

Antiprotozoal Agents / chemistry
Antiprotozoal Agents / metabolism
Antiprotozoal Agents / pharmacology*
Drug Design*
Leishmania / classification
Leishmania / drug effects*
Leishmania / enzymology
Molecular Structure
Molecular Targeted Therapy*
Peptide Hydrolases* / chemistry
Peptide Hydrolases* / metabolism
Protease Inhibitors / chemistry
Protease Inhibitors / metabolism
Protease Inhibitors / pharmacology*
Protein Conformation
Protozoan Proteins / antagonists & inhibitors*
Protozoan Proteins / chemistry
Protozoan Proteins / metabolism
Structure-Activity Relationship

Substances

Antiprotozoal Agents
Protease Inhibitors
Protozoan Proteins
Peptide Hydrolases