Abstract
(-)-Hinokinin (1) is a dibenzylbutyrolactone lignan obtained by the partial synthesis of (-)-cubebin. This study reports the antigenotoxic and anticarcinogenic potential of 1 by the comet and aberrant crypt focus assays in the peripheral blood and colon of 4-5-week-old Wistar rats, respectively. The rats were exposed to 1,2-dimethylhydrazine (40 mg/kg) and were treated by gavage with doses of 10, 20, and 40 mg/kg of 1. The results showed that the dose of 40 mg/kg was neither genotoxic nor carcinogenic. In the comet assay, all 1 doses displayed antigenotoxic effects. In addition, this compound (20 and 40 mg/kg) exhibited an anticarcinogenic effect in the aberrant crypt focus assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1,2-Dimethylhydrazine / pharmacology*
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / chemistry
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4-Butyrolactone / pharmacology
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Animals
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Anticarcinogenic Agents / pharmacology
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Benzodioxoles
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Carcinogens / pharmacology
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Colon / drug effects
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Comet Assay
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DNA Damage / drug effects
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Dimethylhydrazines / chemistry
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Dioxoles / chemistry
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Dioxoles / pharmacology*
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Lignans / chemistry
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Lignans / pharmacology*
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Male
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Molecular Structure
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Piper / chemistry
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Rats
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Rats, Wistar
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Stereoisomerism
Substances
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Anticarcinogenic Agents
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Benzodioxoles
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Carcinogens
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Dimethylhydrazines
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Dioxoles
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Lignans
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hinokinin
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dimazine
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1,2-Dimethylhydrazine
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cubebin
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4-Butyrolactone