Abstract
The acute administration of GR38032F, a selective 5-HT3 receptor antagonist, did not change the concentrations of dopamine (DA) or 5-hydroxytryptamine (5-HT) or their deaminated metabolites in nucleus caudatus, nucleus accumbens or substantia nigra. Pretreatment with GR38032F failed to modify the haloperidol-induced activation of DA turnover. It is concluded that the blockade of central 5-HT3 receptors by GR38032F under these experimental conditions does not result in alternations in metabolism of DA or 5-HT in major ascending dopaminergic areas.
MeSH terms
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3,4-Dihydroxyphenylacetic Acid / metabolism
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Animals
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Biogenic Monoamines / metabolism
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism*
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Dopamine / metabolism*
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Haloperidol / pharmacology
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Homovanillic Acid / metabolism
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Imidazoles / pharmacology*
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Limbic System / drug effects
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Limbic System / metabolism*
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Male
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Neurons / metabolism
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / metabolism
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Ondansetron
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Rats
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Rats, Inbred Strains
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Receptors, Serotonin / drug effects*
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Serotonin / metabolism*
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Substantia Nigra / drug effects
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Substantia Nigra / metabolism*
Substances
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Biogenic Monoamines
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Imidazoles
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Receptors, Serotonin
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3,4-Dihydroxyphenylacetic Acid
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Serotonin
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Ondansetron
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Haloperidol
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Dopamine
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Homovanillic Acid