Using urinary 1-hydroxypyrene concentrations to evaluate polycyclic aromatic hydrocarbon exposure in women using biomass combustion as main energy source

Drug Chem Toxicol. 2015;38(3):349-54. doi: 10.3109/01480545.2014.968932. Epub 2014 Oct 13.

Abstract

Context: The use of solid fuels for cooking and heating is likely to be the largest source of indoor air pollution on a global scale.

Objective: The aim of this study was to investigate the urinary excretion of 1-hydroxypyrene (1-OHP) in women living in a rural community, where biomass combustion is used as main energy source during a working day.

Materials and methods: The study was performed on urine samples collected in 2012, of 30 healthy women who were residents of a rural community in San Luis Potosi, Mexico. Urine was collected from each woman at three time points (morning, post-lunch and evening) during a working day. The analysis of urinary 1-OHP was performed using high-performance liquid chromatography (HPLC). Also, a health-risk assessment was conducted.

Results: The highest levels of 1-OHP in this study were found in the samples taken in the evening (geometric mean ± SD; 0.36 ± 0.13 µg/g creatinine). However, no significant differences among 1-OHP concentrations in the evening and post-lunch samples (0.27 ± 0.10 µg/g creatinine; 0.58 ± 0.67 µg/L) were observed. But, the 1-OHP levels (0.17 ± 0.13 µg/g creatinine; 0.19 ± 0.21 µg/L) found in samples collected in the morning were significantly lower than the 1-OHP levels found in samples collected during post-lunch and evening time.

Discussion and conclusion: The data shown in this study demonstrated an increment in the exposure levels to PAHs in women across the shift. However, no health risk was found in this study.

Keywords: 1-Hydroxypyrene; biomass; biomonitoring; méxico; polycyclic aromatic hydrocarbons; women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Air Pollutants / adverse effects
  • Air Pollutants / metabolism*
  • Air Pollution, Indoor* / adverse effects
  • Biomarkers / urine
  • Biomass*
  • Biotransformation
  • Chromatography, High Pressure Liquid
  • Cooking / methods*
  • Environmental Monitoring / methods
  • Female
  • Heating / adverse effects
  • Heating / methods*
  • Humans
  • Inhalation Exposure* / adverse effects
  • Mexico
  • Middle Aged
  • Polycyclic Aromatic Hydrocarbons / adverse effects
  • Polycyclic Aromatic Hydrocarbons / metabolism*
  • Pyrenes / urine*
  • Risk Assessment
  • Rural Health
  • Time Factors
  • Urinalysis
  • Women's Health
  • Young Adult

Substances

  • Air Pollutants
  • Biomarkers
  • Polycyclic Aromatic Hydrocarbons
  • Pyrenes
  • 1-hydroxypyrene