Abstract
Promoting clearance of intracellular excessive tau is a potential therapeutic strategy for treating Alzheimer's disease. In this work, we designed and synthesized a cyclen-hybrid artificial 'hydrolase' I1-Cu(II) to cleave tau in vitro. Furthermore, a cell-permeable 'hydrolase' I2-Cu(II), derived from I1-Cu(II), was also synthesized to cleave intracellular tau proteins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / therapy
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Copper / chemistry
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Cyclams
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Drug Design
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Heterocyclic Compounds / chemical synthesis
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Hydrolases / chemical synthesis*
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Molecular Structure
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Protein Aggregation, Pathological / prevention & control*
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Recombinant Proteins / genetics
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Recombinant Proteins / metabolism
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tau Proteins / chemistry*
Substances
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Cyclams
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Heterocyclic Compounds
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Recombinant Proteins
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tau Proteins
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Copper
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cyclen
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Hydrolases