Diagnostic accuracy of clinical symptoms and rapid diagnostic test in group A streptococcal perianal infections in children

Robert Cohen; Corinne Levy; Stéphane Bonacorsi; Alain Wollner; Marc Koskas; Camille Jung; Stéphane Béchet; Martin Chalumeau; Jérémie Cohen; Philippe Bidet

doi:10.1093/cid/ciu794

Diagnostic accuracy of clinical symptoms and rapid diagnostic test in group A streptococcal perianal infections in children

Clin Infect Dis. 2015 Jan 15;60(2):267-70. doi: 10.1093/cid/ciu794. Epub 2014 Oct 13.

Authors

Affiliations

¹ Association Clinique et Thérapeutique Infantile du Val de Marne, Saint-Maur des Fossés Clinical Research Center, Centre Hospitalier Intercommunal de Créteil Association Française de Pédiatrie Ambulatoire Unité Court Séjour, Petits Nourrissons, Service de Néonatologie, Centre Hospitalier Intercommunal de Créteil.
² Association Clinique et Thérapeutique Infantile du Val de Marne, Saint-Maur des Fossés Clinical Research Center, Centre Hospitalier Intercommunal de Créteil Association Française de Pédiatrie Ambulatoire.
³ Université Paris Diderot, Sorbonne Paris Cité Service de Microbiologie, Hôpital Robert-Debré
⁴ Association Clinique et Thérapeutique Infantile du Val de Marne, Saint-Maur des Fossés.
⁵ Clinical Research Center, Centre Hospitalier Intercommunal de Créteil.
⁶ Department of Pediatrics, Necker-Enfants-Malades Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes INSERM U1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS), Paris Descartes University, France.
⁷ INSERM U1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team, Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS), Paris Descartes University, France.

PMID: 25313248
DOI: 10.1093/cid/ciu794

Abstract

From 2009 to 2014, we prospectively enrolled 132 children with perianal infections. The presentation of painful defecation, anal fissures, and macroscopic blood in stools was highly suggestive of group A streptococcal perianal infection (probability 83.3%). We found a high sensitivity of a group A streptococcal rapid diagnostic testing (98%) but relatively low specificity (72.8%).

Keywords: children; group A streptococcal; perianal infection; rapid diagnostic test.

Publication types

Comparative Study
Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Anus Diseases / diagnosis*
Anus Diseases / microbiology*
Child
Child, Preschool
Clinical Medicine / methods*
Diagnostic Tests, Routine / methods*
Female
Humans
Male
Prospective Studies
Sensitivity and Specificity
Streptococcal Infections / diagnosis*
Streptococcal Infections / microbiology*
Streptococcus pyogenes / isolation & purification*
Time Factors