Medications, consumed more and more frequently as a result of self-medication or prescribed under medical supervision, have multiple side effects, including dermatological ones. In fact, the latter represent the primary cause of drug intolerance. However, the diagnosis is not always made easily and is based upon standardized norms defined by pharmacology control centers. Fixed pigmented eruptions are the only erythema solely of drug-induced origin. Failure to recognize a drug-induced dermatological manifestation can be fatal if the drug is taken again, as in the case of toxic epidermal necrolysis.