Impact of a new reimbursement program on hepatitis B antiviral medication cost and utilization in Beijing, China

PLoS One. 2014 Oct 16;9(10):e109652. doi: 10.1371/journal.pone.0109652. eCollection 2014.

Abstract

Background: Hepatitis B virus (HBV) infection is a significant clinical and financial burden for chronic hepatitis B (CHB) patients. In Beijing, China, partial reimbursement on antiviral agents was first implemented for the treatment of CHB patients in July 1, 2011.

Aims: In this study, we describe the medical cost and utilization rates of antiviral therapy for CHB patients to explore the impact of the new partial reimbursement policy on the medical care cost, the composition, and antivirals utilization.

Methods: Clinical and claims data of a retrospective cohort of 92,776 outpatients and 2,774 inpatients with non-cirrhotic CHB were retrieved and analyzed from You'an Hospital, Beijing between February 14, 2008 and December 31, 2012. The propensity score matching was used to adjust factors associated with the annual total cost, including age, gender, medical insurance type and treatment indicator.

Results: Compared to patients who paid out-of-pocket, medical cost, especially antiviral costs increased greater among patients with medical insurance after July 1, 2011, the start date of reimbursement policy. Outpatients with medical insurance had 16% more antiviral utilization; usage increased 3% among those who paid out-of-pocket after the new partial reimbursement policy was implemented.

Conclusions: Direct medical costs and antiviral utilization rates of CHB patients with medical insurance were higher than those from paid out-of-pocket payments, even after adjusting for inflation and other factors. Thus, a new partial reimbursement program may positively optimize the cost and standardization of antiviral treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / economics*
  • Antiviral Agents / therapeutic use*
  • China
  • Drug Costs / statistics & numerical data*
  • Drug Utilization / economics*
  • Female
  • Health Services / economics
  • Health Services / statistics & numerical data
  • Hepatitis B, Chronic / drug therapy*
  • Hepatitis B, Chronic / economics*
  • Hospitals / statistics & numerical data
  • Humans
  • Insurance, Health, Reimbursement / statistics & numerical data*
  • Male
  • Retrospective Studies

Substances

  • Antiviral Agents

Grants and funding

This study was supported by the Ministry of National Science and Technology of China (2012ZX10004904), Bristol-Myers Squibb Company (AI463-961), Beijing Municipal and Technology Commission (Z131100004613030) and Innovative Foundation of Beijing Union Medical College. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.