Targeted therapy in sarcomas other than GIST tumors

J Surg Oncol. 2015 Apr;111(5):632-40. doi: 10.1002/jso.23802. Epub 2014 Oct 20.

Abstract

Non-GIST soft tissue sarcomas are a heterogeneous grouping of mesenchymal tumors that comprise less than 1% of adult malignancies. Treatment continues to be based on cytotoxic chemotherapy regimens. However, characterization of the molecular pathway deregulations that drive these tumors has led to the emergence of more customized treatment options. In this review, we focus on the multitude of molecular inhibitors targeting angiogenesis and cell cycle pathways being tested in clinical trials.

Keywords: angiogenesis inhibitors; cell cycle inhibitors; non-GIST soft tissue sarcoma; targeted therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use
  • Antineoplastic Agents / therapeutic use*
  • Cell Cycle / drug effects
  • Gastrointestinal Neoplasms / blood supply
  • Gastrointestinal Neoplasms / drug therapy
  • Gastrointestinal Neoplasms / metabolism
  • Gastrointestinal Neoplasms / pathology
  • Gastrointestinal Stromal Tumors / blood supply
  • Gastrointestinal Stromal Tumors / drug therapy
  • Gastrointestinal Stromal Tumors / metabolism
  • Gastrointestinal Stromal Tumors / pathology
  • Humans
  • Molecular Targeted Therapy
  • Sarcoma / blood supply
  • Sarcoma / drug therapy*
  • Sarcoma / metabolism
  • Sarcoma / pathology

Substances

  • Angiogenesis Inhibitors
  • Antineoplastic Agents