Abstract
Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.
Keywords:
Nanoparticles; biologics; solvent-free; therapeutic proteins; thermosponge.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / administration & dosage*
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Anti-Inflammatory Agents / pharmacokinetics
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Anti-Inflammatory Agents / pharmacology
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Cell Line
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Delayed-Action Preparations / chemistry*
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Drug Delivery Systems
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Humans
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Hypoglycemic Agents / administration & dosage*
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Hypoglycemic Agents / pharmacokinetics
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Hypoglycemic Agents / pharmacology
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Insulin / administration & dosage*
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Insulin / pharmacokinetics
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Insulin / pharmacology
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Interleukin-10 / administration & dosage*
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Interleukin-10 / pharmacokinetics
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Interleukin-10 / pharmacology
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Mice
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Nanoparticles / chemistry*
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Nanoparticles / ultrastructure
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Polymers / chemistry*
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Temperature
Substances
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Anti-Inflammatory Agents
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Delayed-Action Preparations
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Hypoglycemic Agents
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Insulin
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Polymers
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Interleukin-10