Light-driven directed proton transport across the liposomal membrane

Romina Zappacosta; Gabriella Siani; Serena Silvi; Alberto Credi; Antonella Fontana

doi:10.1021/la503604e

Light-driven directed proton transport across the liposomal membrane

Langmuir. 2014 Nov 18;30(45):13667-72. doi: 10.1021/la503604e. Epub 2014 Nov 6.

Authors

Romina Zappacosta¹, Gabriella Siani, Serena Silvi, Alberto Credi, Antonella Fontana

Affiliation

¹ Dipartimento di Farmacia, Università degli Studi "Gabriele d'Annunzio" , Via dei Vestini, I-66100 Chieti, Italy.

PMID: 25343334
DOI: 10.1021/la503604e

Abstract

We have developed a simple artificial photoresponsive ion-gating device by inserting molecular switches in the membrane of liposomes. A controlled and directed proton transport across the bilayer membrane can lower the internal pH of the liposomes from neutral to around 4 under combined light and chemical stimulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydrogen-Ion Concentration
Light*
Lipid Bilayers / chemistry*
Liposomes / chemistry*
Molecular Structure
Phosphatidylcholines / chemistry*
Protons*

Substances

Lipid Bilayers
Liposomes
Phosphatidylcholines
Protons
1-palmitoyl-2-oleoylphosphatidylcholine