Abstract
Four new polyketides, amphidinins C-F (1-4), have been isolated from the culture broth of symbiotic dinoflagellate Amphidinium sp. The analysis of their spectral data revealed that amphidinins C-F (1-4) were 4,5-seco-analogues of amphidinolide Q (5). The absolute configurations of the new compounds were elucidated by the combination of J-based configuration analysis, modified Mosher's method, and chemical derivatization. Amphidinins D (2) and F (4) are the first glycosides related to amphidinolides. Amphidinins C-F (1-4) showed antimicrobial activity against bacteria and/or fungi.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Dinoflagellida / chemistry*
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Dinoflagellida / isolation & purification
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Macrolides / chemical synthesis*
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Macrolides / chemistry
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Macrolides / isolation & purification
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Magnetic Resonance Spectroscopy
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Marine Toxins / chemistry*
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Marine Toxins / isolation & purification
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Marine Toxins / pharmacology*
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Molecular Structure
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Polyketides / chemistry*
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Polyketides / isolation & purification
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Stereoisomerism
Substances
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Anti-Infective Agents
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Macrolides
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Marine Toxins
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Polyketides
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amphidinolide Q