Identifying novel biomarkers through data mining-a realistic scenario?

Proteomics Clin Appl. 2015 Apr;9(3-4):437-43. doi: 10.1002/prca.201400107. Epub 2015 Jan 12.

Abstract

In this article we discuss the requirements to use data mining of published proteomics datasets to assist proteomics-based biomarker discovery, the use of external data integration to solve the issue of inadequate small sample sizes and finally, we try to estimate the probability that new biomarkers will be identified through data mining alone.

Keywords: Bioinformatics; Biomarker; Data mining; Databases; Mass spectrometry.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / analysis*
  • Computational Biology / methods
  • Data Mining / methods*
  • Mass Spectrometry / methods
  • Proteomics / methods

Substances

  • Biomarkers