Recent progress in direct introduction of fluorinated groups on alkenes and alkynes by means of C-H bond functionalization

Chemistry. 2014 Dec 15;20(51):16830-45. doi: 10.1002/chem.201404537. Epub 2014 Oct 27.

Abstract

The direct introduction of fluorine and fluorinated building blocks has recently attracted a lot of attention and particularly the direct functionalization of alkenes and alkynes. This review will highlight the major progress recently made in that field, with a focus on photocatalyzed transformations, base-promoted processes, and transition metal-catalyzed functionalization of alkenes and alkynes. Special attention will be paid to explanations of the reaction mechanisms.

Keywords: alkenes; alkynes; fluorination; radical reactions; trifluoromethylation.