Hereditary thyroid cancer syndromes and genetic testing

J Surg Oncol. 2015 Jan;111(1):51-60. doi: 10.1002/jso.23769. Epub 2014 Oct 28.

Abstract

This review focuses on both hereditary medullary thyroid cancer (MTC) and hereditary nonmedullary thyroid cancer (NMTC) and discusses the genetics, clinical diagnosis and evaluation, and surgical approach to treatment of these malignancies. Areas of innovation as well as areas of debate are highlighted and management recommendations are made.

Keywords: hereditary thyroid cancer; medullary thyroid cancer; multiple endocrine neoplasia; nonmedullary thyroid cancer; ret proto oncogene.

Publication types

  • Review

MeSH terms

  • Genetic Testing*
  • Humans
  • Neoplastic Syndromes, Hereditary / diagnosis*
  • Neoplastic Syndromes, Hereditary / genetics*
  • Proto-Oncogene Mas
  • Thyroid Neoplasms / diagnosis*
  • Thyroid Neoplasms / genetics*