The influence of interleukin-7 receptor α-chain haplotypes on outcome after allogeneic hematopoietic cell transplantation

Int J Immunogenet. 2014 Dec;41(6):521-7. doi: 10.1111/iji.12158. Epub 2014 Oct 29.

Abstract

We investigated the influence of IL-7 receptor α-chain (IL-7Rα) gene haplotypes in donors on the outcome of haematopoietic cell transplantation (HCT). Unlike the association between single donor SNPs and HCT outcome found previously, only trends towards association were found here, due to 'dilution' of SNPs into haplotypes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Gene Frequency / genetics
  • Haplotypes / genetics*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Receptors, Interleukin-7 / genetics*
  • Transplantation, Homologous
  • Treatment Outcome
  • Young Adult

Substances

  • Receptors, Interleukin-7
  • interleukin-7 receptor, alpha chain