Abstract
Alstoscholarisines A-E (1-5), five unprecedented monoterpenoid indole alkaloids with 6/5/6/6/6 fused-bridge rings, were isolated from Alstonia scholaris. They promoted adult neuronal stem cells (NSCs) proliferation significantly, in which the most active one (1) functioned from a concentration of 0.1 μg/mL in a dosage-dependent manner. Furthermore, 1 enhanced NSC sphere formation and neurogenic fate commitment through activation of a Wnt signaling pathway and promoted NSC differentiation but did not affect proliferation of neuroblastoma cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alstonia / chemistry*
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Cell Differentiation
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Cell Proliferation / drug effects*
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Heterocyclic Compounds, 4 or More Rings / chemistry*
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Heterocyclic Compounds, 4 or More Rings / isolation & purification
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Heterocyclic Compounds, 4 or More Rings / metabolism*
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Indole Alkaloids / chemistry*
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Indoles / chemistry*
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Indoles / isolation & purification
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Indoles / metabolism*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Neural Stem Cells / chemistry*
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Neural Stem Cells / cytology*
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Neural Stem Cells / metabolism
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Plant Leaves
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Secologanin Tryptamine Alkaloids / chemistry*
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Secologanin Tryptamine Alkaloids / isolation & purification
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Secologanin Tryptamine Alkaloids / metabolism
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Wnt Signaling Pathway / drug effects
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Wnt Signaling Pathway / physiology*
Substances
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Heterocyclic Compounds, 4 or More Rings
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Indole Alkaloids
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Indoles
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Secologanin Tryptamine Alkaloids
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alistonitrine A
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alstoscholarine